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KMID : 0385020010170040257
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Korean Journal of Laboratory Animal Science
2001 Volume.17 No. 4 p.257 ~ p.261
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Changes of Neuropeptide Y Immunoreactivity in Periventricular Hypothalamic Nucleus and Paraventricular Thalamic Nucleus of the Aged Spontaneously Hypertensive Rats
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Abstract
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This study have elcplored certain changes with aging of NPY-immnureactivity of the periventricular hypothalamic nucleus (PHN) and paraventricular thalamic nucleus (PTN) in the spontaneously hypertensive (SHR) and normatensive Wistar Kyoto rats (WKY). Changes of NPY-immunoreactive fibers with aging in the PHN and PTN of aged SHR and aged WKY rats were demonstrated by immunohistochemistry. In the 3 month-old WAY rats, the high density of NPY-immunoreactive fibers was observed in the PHN and PTN. Similar NPY-inununareactivity was showed in the PHN and PTN of the SHIt. In the 18 month-old group, the ale-related decreases were slightly observed in WKY and there were no significant differences in 51IR compared to the 3 month-old in the PTN and PHN. However, compared to 18 month-old SHR and WKY, the age-induced decreases were showed in PHN of the SHR. No differences were showed in the PTN. In the 22 month-old SHR, more decreasing NPY-immunoreactivity was observed in the PHN and PTN.
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KEYWORD
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